POLYOXYETHYLENE FATTY ACID
The STANDARD GUJCHEM RANGE.
GUJCHEM SEA series based on Stearic Acid click here
GUJCHEM LEA series based on Lauric Acid click here
GUJCHEM OEA series based on Oleic Acid click here
GUJCHEM MEA series based on Myristic Acid click here
GUJCHEM CEA series based on Coconut
Fatty Acid click here |
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Physical and Analytical Data
STEARIC ACID ETHOXYLATE (SEA)
GUJCHEM |
APPEARANCE AT 25° c |
SAPO-
NIFICATION VALUE |
IODINE VALUE |
HLB |
ACID VALUE |
MOLECULAR WEIGHT |
MELTING POINT |
SEA-5.0 |
Soft solid |
111±5 |
≤1.0 |
8.89 |
111-117 |
≈ 505 |
28 |
SEA-6.5 |
Soft solid |
100±5 |
≤1.0 |
9.7 |
99-105 |
≈ 570 |
28 |
SEA-8 |
Waxy cream |
89±5 |
≤1.0 |
11.1 |
89-95 |
≈ 637 |
30 |
SEA-10 |
Pasty solid |
78±5 |
≤1.0 |
12.6 |
83-87 |
≈ 725 |
31 |
SEA-12 |
Pasty solid |
70±5 |
≤1.0 |
13.00 |
67-73 |
≈ 813 |
32 |
SEA-20 |
Waxy solid |
61±5 |
≤1.0 |
15.12 |
46-52 |
≈ 1165 |
34 |
SEA-30 |
Waxy solid |
53±5 |
≤1.0 |
16.46 |
32-38 |
≈ 1605 |
36 |
SEA-40 |
Waxy solid with a faint, bland, fat like odor, off white to light tan in color |
42±5 |
≤1.0 |
17.22 |
24-30 |
≈ 2046 |
38 |
SEA-50 |
Solid with a bland, fat like odor or odorless |
35±5 |
≤1.0 |
17.71 |
19-25 |
≈ 2486 |
42 |
LAURIC ACID ETHOXYLATE (LEA)
GUJCHEM |
APPEARANCE AT 25° c |
SAPO-
NIFICATION VALUE |
IODINE VALUE |
HLB |
MOLECULAR WEIGHT |
PH |
LEA-5.0 |
Soft solid viscous |
135±5 |
≤ 0.5 |
10.48 |
≈ 420 |
6.00-8.00 |
LEA-6.5 |
Soft solid viscous |
117±5 |
≤ 0.5 |
11.77 |
≈ 486 |
6.00-8.00 |
LEA-8.0 |
Clear liquid |
103±5 |
≤ 0.5 |
12.75 |
≈ 552 |
6.00-8.00 |
LEA-10 |
Clear liquid |
89±5 |
≤ 0.5 |
13.75 |
≈ 640 |
6.00-8.00 |
LEA-15 |
Pasty liquid |
66±5 |
≤ 0.1 |
15.35 |
≈ 861 |
6.00-8.00 |
LEA-20 |
Waxy solid |
52±5 |
≤ 0.1 |
16.30 |
≈ 1081 |
6.00-8.00 |
LEA-30 |
Waxy solid |
37±5 |
≤ 0.1 |
17.37 |
≈ 1521 |
6.00-8.00 |
LEA-40 |
Waxy solid |
29±5 |
≤ 0.1 |
17.96 |
≈ 1962 |
6.00-8.00 |
OLEIC ACID ETHOXYLATE (OEA)
GUJCHEM |
SAPO-
NIFICATION VALUE |
IODINE VALUE |
HLB |
ACID VALUE |
MOLECULAR WEIGHT |
PH |
OEA-5.0 |
111±5 |
52-57 |
8.89 |
111-113 |
≈ 502 |
6.00-8.00 |
OEA-6.5 |
99±5 |
47-52 |
10.10 |
99-102 |
≈ 568 |
6.00-8.00 |
OEA-8 |
89±5 |
42-47 |
11.11 |
89-91 |
≈ 634 |
6.00-8.00 |
OEA-10 |
78±5 |
37-41 |
12.19 |
78-80 |
≈ 723 |
6.00-8.00 |
OEA-15 |
61±5 |
28-31 |
14.01 |
59-61 |
≈ 943 |
6.00-8.00 |
OEA-20 |
49±5 |
23-26 |
15.15 |
48-50 |
≈ 1163 |
6.00-8.00 |
OEA-30 |
35±5 |
17-20 |
16.49 |
35-37 |
≈ 1603 |
6.00-8.00 |
OEA-40 |
28±5 |
13-15 |
17.24 |
27-29 |
≈ 2045 |
6.00-8.00 |
MYRISTIC ACID ETHOXYLATE (MEA)
GUJCHEM |
SAPO-
NIFICATION VALUE |
PH VALUE |
HLB |
MOISTURE CONTENT MAX. |
MOLECULAR WEIGHT |
MEA-5.0 |
101±5 |
6.00-8.00 |
9.85 |
≤1.0 |
≈ 449 |
MEA-6.5 |
88±5 |
6.00-8.00 |
11.11 |
≤1.0 |
≈ 515 |
MEA-8 |
78±5 |
6.00-8.00 |
12.16 |
≤1.0 |
≈ 581 |
MEA-10 |
68±5 |
6.00-8.00 |
13.17 |
≤1.0 |
≈ 669 |
MEA-15 |
64±5 |
6.00-8.00 |
14.87 |
≤1.0 |
≈ 889 |
MEA-20 |
61±5 |
6.00-8.00 |
15.88 |
≤1.0 |
≈ 1110 |
MEA-30 |
44±5 |
6.00-8.00 |
17.05 |
≤1.0 |
≈ 1550 |
COCONUT FATTY ACID ETHOXYLATE (CEA)
GUJCHEM |
SAPO-
NIFICATION VALUE |
PH VALUE |
HLB |
MOISTURE CONTENT MAX. |
MOLECULAR WEIGHT |
IODINE VALUE |
CEA-5.0 |
134±5 |
6.00-8.00 |
10.02 |
≤1 |
≈ 435 |
5±1 |
CEA-6.5 |
117±5 |
6.00-8.00 |
11.50 |
≤1 |
≈ 501 |
5±1 |
CEA-8.0 |
103±5 |
6.00-8.00 |
12.50 |
≤1 |
≈ 567 |
4±1 |
CEA-10 |
89±5 |
6.00-8.00 |
13.50 |
≤1 |
≈ 655 |
3±1 |
CEA-15 |
67±5 |
6.00-8.00 |
15.00 |
≤1 |
≈ 875 |
3±1 |
CEA-20 |
54±5 |
6.00-8.00 |
16.00 |
≤1 |
≈ 1095 |
2±1 |
CEA-30 |
38±5 |
6.00-8.00 |
17.00 |
≤1 |
≈ 1535 |
1±1 |
CEA-40 |
30±5 |
6.00-8.00 |
19.05 |
≤1 |
≈ 1975 |
1±1 |
Functional Category
Emulsifying agent; solubilizing agent; wetting agent.
APPLICATIONS IN PHARMACEUTICAL FORMULATION OR TECHNOLOGY
GUJCHEM-SEA are generally used as emulsifiers in oil-in-water type creams and lotions. Their hydrophilicity or lipophilicity depends on the number of ethylene oxide units present; the larger the number, the greater the hydrophilic properties. GUJCHEM-SEA-40 has also been used as an emulsifying agent in intravenous infusions.
GUJCHEM-SEA are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present.
They can also be blended with other surfactants to obtain any hydrophilic-lipophilic balance for lotions or ointment formulations.
Use |
Concentration |
Auxiliary emulsifier for o/w intravenous fat emulsion |
0.5-5 |
Emulsifier for o/w creams or lotions |
0.5-10 |
Ophthalmic ointment |
7 |
Suppository component |
1-10 |
Tablet lubricant |
1-2 |
SOLUBILITY
Name |
Solvent Ethanol (95%) |
Mineral Oil |
Water |
GUJCHEM SEA-6 |
S |
S |
DH |
GUJCHEM SEA-8 |
S |
I |
D |
GUJCHEM SEA-12 |
S |
I |
S |
GUJCHEM SEA-20 |
S |
I |
S |
GUJCHEM SEA-40 |
S |
I |
S |
GUJCHEM SEA-50 |
S |
I |
S |
Where
D = Dispersible, S = Soluble, I = Insoluble and DH = Dispersible (with Heat)
STABILITY AND STORAGE
GUJCHEM-SEA are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
The bulk material should be stored in a well-closed container, in a dry place, at room temperature.
INCOMPATIBILITIES
GUJCHEM-SEA are unstable in hot alkaline solutions due to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts and salts of bismuth, silver and tannins. Complex formation with preservatives may also occur.
The antimicorbial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin and tetracycline may be, reduced in the presence of GUJCHEM-SEA concentrations greater than 5% w/w.
SAFETY
Although GUJCHEM-SEA are primarily used as emulsifying agents in topical pharmaceutical formulations certain materials, particularly GUJCHEM-SEA-40 have also been used intravenous injections and oral preparations.
GUJCHEM-SEA have been extensively tested for toxicity in animals and are widely used in pharmaceutical formulations and cosmetics. They are generally regarded as essentially nontoxic and nonirritant materials.
HANDLING PRECAUTIONS
Observe normal precautions appropriate to the circumstances and quantity of material handled.
GUJCHEM-SEA that contain greater than 100 ppm of free ethylene oxide may present an explosion hazard when stored in a closed container. This is due to the release of ethylene oxide into the container headspace where it can accumulate, and so exceed the explosion limit.
Note: Above
Gujchem Range are the running products. We can produce higher moles
on customer specific demand and specifications can be altered as per
customer requirement.
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